The area covered by the mist directly depends on the spray plume geometry, which can be tailored with the nozzle fluid path geometry and flow rate between 25° and 60°. The Ad-Mist nozzle is capable of delivering a homogenous distribution of droplets to a surface. As the biologic and controlled-release formulation markets grow, there is a huge need to overcome high-viscosity formulation challenges with specific spray devices.Īirless and Propellant-Free Spray Delivery For example, they could include high molecular weight polymers or other vehicles, increasing the viscosity of the entire formulation. There are several technical strategies that can be used to develop a controlled release formulation, but the main challenge is that they could be difficult to deliver. These long-acting formulations are intended to reduce the required dosing frequency of a therapy, improving patient compliance and reducing impact on healthcare costs. The second key factor is the increasing development of sustained/controlled release formulations. Biosimilars have also entered the market, creating a highly competitive landscape. Monoclonal antibodies (mAbs) are expected to reach combined global sales of US$150 billion (£134 billion) by 2022. The first one is the significant growth of biologics. This new paradigm could be attributed to several key factors. High-viscosity formulations have become increasingly prevalent over the last few years in the pharmaceutical industry.
Delivery in any patient posture, in particular, in any patient’s head position for intranasal, buccal or auricular administration.Indeed, spray- or mist-based delivery presents many advantages over conventional methods: Over many years, a variety of spray devices have been developed, such as nasal or buccal sprays, inhalation systems and even spray-on bandage devices. This is an advantage when rapid drug absorption and onset of action are desired.ĭepending on the route of administration, the formulation and the dosage, a delivery device may be needed to properly administer the drug. Compared with the conventional oral and parenteral routes, it is claimed that topical administration offers the advantages of being non-invasive and avoiding first-pass metabolism in the liver by enabling the drug to enter directly into the circulatory system. The choice of delivery route for a drug depends not only on the site of desired action, but also on its properties – its absorption by the body and the environment in which it will be administered. There is a huge need to overcome high-viscosity formulation challenges with specific spray devices.” “As the biologic and controlled-release formulation markets grow,
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However, drugs can also be delivered via other routes, such as the enteral route through tubing in the gastro-intestinal tract, inhalation to the lungs via the mouth or even the topical route via the skin (cutaneous, transdermal) or a mucosa (intranasal, buccal, auricular, ophthalmic, etc). When one thinks of drug administration, one usually thinks of swallowing pills (oral administration) or getting an injection (parenteral administration).
Over the past decades, drug delivery has evolved and new routes of administration have emerged. SPRAY DELIVERY AS A NEWROUTE OF ADMINISTRATION
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